La maladie de Parkinson au Canada (serveur d'exploration)

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LINGO1 Variants in the French-Canadian Population

Identifieur interne : 001742 ( Main/Exploration ); précédent : 001741; suivant : 001743

LINGO1 Variants in the French-Canadian Population

Auteurs : Cynthia V. Bourassa [Canada] ; Jean-Baptiste Rivière [Canada] ; Patrick A. Dion [Canada] ; Geneviève Bernard [Canada] ; Sabrina Diab [Canada] ; Michel Panisset [Canada] ; Sylvain Chouinard [Canada] ; Nicolas Dupré [Canada] ; Hélène Fournier [Canada] ; John Raelson [Canada] ; Majid Belouchi [Canada] ; Guy A. Rouleau [Canada]

Source :

RBID : PMC:3019170

Abstract

Essential tremor (ET) is a complex genetic disorder for which no causative gene has been found. Recently, a genome-wide association study reported that two variants in the LINGO1 locus were associated to this disease. The aim of the present study was to test if this specific association could be replicated using a French-Canadian cohort of 259 ET patients and 479 ethnically matched controls. Our genotyping results lead us to conclude that no association exists between the key variant rs9652490 and ET (Pcorr = 1.00).


Url:
DOI: 10.1371/journal.pone.0016254
PubMed: 21264305
PubMed Central: 3019170


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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Variants in the French-Canadian Population</title>
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Variants in the French-Canadian Population</title>
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<p>Essential tremor (ET) is a complex genetic disorder for which no causative gene has been found. Recently, a genome-wide association study reported that two variants in the
<italic>LINGO1</italic>
locus were associated to this disease. The aim of the present study was to test if this specific association could be replicated using a French-Canadian cohort of 259 ET patients and 479 ethnically matched controls. Our genotyping results lead us to conclude that no association exists between the key variant rs9652490 and ET (
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<name sortKey="Ross, Oa" uniqKey="Ross O">OA Ross</name>
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<name sortKey="Jasinska Myga, B" uniqKey="Jasinska Myga B">B Jasinska-Myga</name>
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<author>
<name sortKey="Kachergus, J" uniqKey="Kachergus J">J Kachergus</name>
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<name sortKey="Zuo, X" uniqKey="Zuo X">X Zuo</name>
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<name sortKey="Jiang, H" uniqKey="Jiang H">H Jiang</name>
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<author>
<name sortKey="Guo, Jf" uniqKey="Guo J">JF Guo</name>
</author>
<author>
<name sortKey="Yu, Rh" uniqKey="Yu R">RH Yu</name>
</author>
<author>
<name sortKey="Sun, Qy" uniqKey="Sun Q">QY Sun</name>
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</analytic>
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<biblStruct>
<analytic>
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<name sortKey="Lin, Pi" uniqKey="Lin P">PI Lin</name>
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<name sortKey="Vance, Jm" uniqKey="Vance J">JM Vance</name>
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<author>
<name sortKey="Pericak Vance, Ma" uniqKey="Pericak Vance M">MA Pericak-Vance</name>
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<author>
<name sortKey="Martin, Er" uniqKey="Martin E">ER Martin</name>
</author>
</analytic>
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<analytic>
<author>
<name sortKey="Dickson, Sp" uniqKey="Dickson S">SP Dickson</name>
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<name sortKey="Wang, K" uniqKey="Wang K">K Wang</name>
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<author>
<name sortKey="Krantz, I" uniqKey="Krantz I">I Krantz</name>
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<author>
<name sortKey="Hakonarson, H" uniqKey="Hakonarson H">H Hakonarson</name>
</author>
<author>
<name sortKey="Goldstein, Db" uniqKey="Goldstein D">DB Goldstein</name>
</author>
</analytic>
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<analytic>
<author>
<name sortKey="Purcell, S" uniqKey="Purcell S">S Purcell</name>
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<author>
<name sortKey="Neale, B" uniqKey="Neale B">B Neale</name>
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<author>
<name sortKey="Todd Brown, K" uniqKey="Todd Brown K">K Todd-Brown</name>
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<author>
<name sortKey="Thomas, L" uniqKey="Thomas L">L Thomas</name>
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<name sortKey="Bourassa, Cynthia V" sort="Bourassa, Cynthia V" uniqKey="Bourassa C" first="Cynthia V." last="Bourassa">Cynthia V. Bourassa</name>
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<name sortKey="Dion, Patrick A" sort="Dion, Patrick A" uniqKey="Dion P" first="Patrick A." last="Dion">Patrick A. Dion</name>
<name sortKey="Dupre, Nicolas" sort="Dupre, Nicolas" uniqKey="Dupre N" first="Nicolas" last="Dupré">Nicolas Dupré</name>
<name sortKey="Fournier, Helene" sort="Fournier, Helene" uniqKey="Fournier H" first="Hélène" last="Fournier">Hélène Fournier</name>
<name sortKey="Panisset, Michel" sort="Panisset, Michel" uniqKey="Panisset M" first="Michel" last="Panisset">Michel Panisset</name>
<name sortKey="Raelson, John" sort="Raelson, John" uniqKey="Raelson J" first="John" last="Raelson">John Raelson</name>
<name sortKey="Riviere, Jean Baptiste" sort="Riviere, Jean Baptiste" uniqKey="Riviere J" first="Jean-Baptiste" last="Rivière">Jean-Baptiste Rivière</name>
<name sortKey="Rouleau, Guy A" sort="Rouleau, Guy A" uniqKey="Rouleau G" first="Guy A." last="Rouleau">Guy A. Rouleau</name>
<name sortKey="Rouleau, Guy A" sort="Rouleau, Guy A" uniqKey="Rouleau G" first="Guy A." last="Rouleau">Guy A. Rouleau</name>
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</record>

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